Population
Human platelets, including platelets from a thrombasthenic patient lacking alpha(IIb)beta(3)
Comparison
Thrombin induction, mechanical stirring, and… vs Unstirred platelets, absence of thrombin, or…
Design
Preclinical
Authors
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Platelet JNK1/ERK2 pathways should not yet influence therapy; extends mechanistic insights but remains hypothesis-generating for antithrombotic targets.
This study demonstrates that MAP kinases JNK1 and ERK2 in human platelets are positively regulated by thrombin and mechanical forces, and negatively regulated by integrin alpha(IIb)beta(3) engagement.
Bugaud et al. (1999) studied this question.
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