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September 1, 1997Journal of Biological ChemistryOpen Access

Negative Regulation of Mitogen-activated Protein Kinase Activation by Integrin αIIbβ3 in Platelets

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Population

Human platelets (normal and thrombasthenic)

Comparison

Inhibition of integrin αIIbβ3 (using RGDS ligand… vs Normal thrombin-induced platelet aggregation…

Design

Preclinical

Authors

FNFlorence NadalEADA Business SchoolSLS Lévy-ToledanoHôpital Saint-LouisFGFrançoise GrelacDélégation Paris 5

Discussion

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Overview

Does not inform antiplatelet strategies; leaves open whether αIIbβ3-ERK2 regulation affects human thrombosis.

Structured PICO

P
Population
Human platelets (normal and thrombasthenic)
I
Intervention
Inhibition of integrin αIIbβ3 (using RGDS ligand peptide or AP-2 monoclonal antibody (Fab')2 fragments) or absence of stirring
C
Comparator
Normal thrombin-induced platelet aggregation without αIIbβ3 inhibition
O
Outcome
ERK2 phosphorylation and activitysurrogate

This study provides the first evidence that integrin engagement (αIIbβ3 during platelet aggregation) down-regulates the MAP kinase pathway (ERK2 activation).

Cite This Study

Nadal et al. (1997) studied this question.

synapsesocial.com/papers/6a702ead5671bbf00bc2a977https://doi.org/10.1074/jbc.272.36.22381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-21995 · 270 citations
  2. 2Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.1994 · 229 citations
  3. 3Stimulation of Mitogen-activated Protein Kinase and Na+/H+ Exchanger in Human Platelets1996 · 87 citations
  4. 4Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets1996 · 76 citations
  5. 5Transforming growth factor <i>β</i> 1 inhibits mitogen-activated protein kinase induced by basic fibroblast growth factor in smooth muscle cells1996 · 25 citations