Population
Mouse platelets genetically deficient in PKC beta and Chinese hamster ovary cell model system
Comparison
PKC inhibitors, genetic deficiency of PKC beta… vs Wild-type platelets or cells
Design
Preclinical
Authors
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May warrant human platelet studies; leaves open PKC beta as antithrombotic target.
The interaction of integrin alpha(IIb)beta(3) with activated PKC beta, mediated by RACK1, is required for platelet spreading on fibrinogen.
Buensuceso et al. (2004) studied this question.
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