Why the study?
Salt sensitivity and inverse salt sensitivity are associated with increased incidence of hypertension, but the prevalence of inverse salt sensitivity in normotensive adults and its association with demographic characteristics remained to be determined.
What is the prevalence of inverse salt sensitivity in healthy normotensive adults, and is it associated with demographic factors?
Population
84 healthy normotensive, nonobese adults
Comparison
7-day low-sodium diet vs 7-day high-sodium diet
Design
Controlled feeding study
Authors
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ISS may be more common in lean normotensives; this observational association leaves open any role in risk stratification or dietary guidance.
What is the prevalence of inverse salt sensitivity in healthy normotensive adults, and is it associated with demographic factors?
Inverse salt sensitivity is present in approximately 10-20% of healthy normotensive adults and appears to be associated with lower BMI.
Romberger et al. (2023) studied this question.
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