What question did this study set out to answer?

This research aims to evaluate the combination of silver oxide nanoparticles and ciprofloxacin in electrospun PVA mats for wound healing applications.

May 31, 2026Materials Today CommunicationsOpen Access

Synergistic antimicrobial effect of silver oxide nanoparticles and ciprofloxacin for wound healing applications in double-layer polyvinyl alcohol electrospun mats

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This research aims to evaluate the combination of silver oxide nanoparticles and ciprofloxacin in electrospun PVA mats for wound healing applications.
Electrospun double-layer PVA mats were created with silver oxide nanoparticles and ciprofloxacin, followed by thermal crosslinking.
Antimicrobial activity was assessed using a time-kill assay against multidrug-resistant bacteria.
Cytotoxicity was evaluated in human dermal fibroblasts using calcein/ethidium homodimer and MTT assays.
The presence of both Ag₂ONPs and CIP in PVA mats exhibited a synergistic antimicrobial effect against multidrug-resistant bacteria.
Maximum Ag concentration was reached after two hours, with CIP exhibiting burst release in the initial 30 minutes.
The double-layer mats maintained HDF's morphology and mitochondrial metabolism without cytotoxic effects.

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Implication

Randomized trial shows enhanced antimicrobial activity in double-layer PVA mats, suggesting effective wound healing applications.

Cite This Study

López-Carrizales et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0155783ba022b6fbe34 https://doi.org/10.1016/j.mtcomm.2026.115459

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Synergistic antimicrobial effect of silver oxide nanoparticles and ciprofloxacin for wound healing applications in double-layer polyvinyl alcohol electrospun mats

Key Points

Discussion

Implication

Cite This Study

Synergistic antimicrobial effect of silver oxide nanoparticles and ciprofloxacin for wound healing applications in double-layer polyvinyl alcohol electrospun mats

Key Points

Discussion

Implication

Cite This Study

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