Why the study?
Does hypertension increase mortality from cardiovascular disease and diabetic nephropathy in Pima Indians with and without type 2 diabetes?
Does hypertension increase mortality from cardiovascular disease and diabetic nephropathy in Pima Indians with and without type 2 diabetes?
In Pima Indians, hypertension strongly predicts cardiovascular death in nondiabetics, but in diabetics, it primarily drives mortality through diabetic nephropathy rather than cardiovascular disease.
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Hypertension may differentially influence mortality pathways by diabetes status; hypothesis-generating and requires validation beyond this cohort.
Sievers et al. (1999) studied this question.
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