What question did this study set out to answer?

To determine whether daily tadalafil preserves erectile function and improves sexual or marital satisfaction in men undergoing radiotherapy for prostate cancer.

April 1, 2014JAMAOpen Access

Tadalafil for Prevention of Erectile Dysfunction After Radiotherapy for Prostate Cancer

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To determine whether daily tadalafil preserves erectile function and improves sexual or marital satisfaction in men undergoing radiotherapy for prostate cancer.
Stratified, double-blind, placebo-controlled trial across 76 medical sites in the United States and Canada enrolling 242 men with intact erectile function receiving external beam radiotherapy (63%) or brachytherapy (37%) (NCT00931528).
Participants were randomly assigned 1:1 to receive daily tadalafil 5 mg (n=121) or placebo (n=121) for 24 weeks starting with radiation therapy.
Off-drug spontaneous erectile function, overall sexual function, and partner satisfaction were evaluated using validated instruments at 28 to 30 weeks and at 1 year.
At 28 to 30 weeks, spontaneous erectile function was retained by 79% (80/101; 95% CI, 70%-88%) in the tadalafil group versus 74% (61/82; 95% CI, 63%-85%) in the placebo group, showing an absolute difference of 5% (95% CI, -9% to 19%; P = .49).
At 1 year, retention of spontaneous erections remained statistically comparable between tadalafil (72%; 95% CI, 60%-84%) and placebo (71%; 95% CI, 59%-84%; P = .93).
Tadalafil did not produce statistically significant improvements in participant overall sexual function, domain subscales, partner-reported sexual satisfaction, or marital adjustment at any assessment interval.

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Implication

Randomized double-blind trial shows daily tadalafil does not prevent erectile dysfunction in men receiving prostate cancer radiotherapy, indicating routine preventive use is ineffective.

Cite This Study

Pisansky et al. (2014) studied this question.

synapsesocial.com/papers/6a1bd4aebc71fb1015a9040a https://doi.org/10.1001/jama.2014.2626

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Implication

Randomized double-blind trial shows daily tadalafil does not prevent erectile dysfunction in men receiving prostate cancer radiotherapy, indicating routine preventive use is ineffective.

Tadalafil for Prevention of Erectile Dysfunction After Radiotherapy for Prostate Cancer

Key Points

Discussion

Implication

Cite This Study

Tadalafil for Prevention of Erectile Dysfunction After Radiotherapy for Prostate Cancer

Key Points

Discussion

Implication

Cite This Study

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