Why the study?
The three main cardiac amyloidosis types have different progression and prognosis, but little is known about their specific modes of death.
What are the specific modes of death in patients with different subtypes of cardiac amyloidosis (AL, ATTRv, ATTRwt)?
Population
566 patients with AL, ATTRv, or ATTRwt cardiac amyloidosis at a French referral centre
Comparison
Mode of death compared across AL, ATTRv, and ATTRwt subtypes
Design
Retrospective study with blinded central committee adjudication
Follow-up
864 patient-years
Authors
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Emphasizes HF surveillance and infection prevention in cardiac amyloidosis; leaves open subtype-specific prevention strategies.
What are the specific modes of death in patients with different subtypes of cardiac amyloidosis (AL, ATTRv, ATTRwt)?
In patients with cardiac amyloidosis, the predominant mode of death is cardiovascular (specifically worsening heart failure), though sudden death is notably frequent in the AL subtype and infection is the leading non-cardiovascular cause.
Kharoubi et al. (2022) studied this question.
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