Why the study?
Does angiotensin II inhibition by saralasin improve hemodynamics in normotensive patients with chronic congestive heart failure?
Population
18 normotensive patients with chronic congestive heart failure and 5 controls
Comparison
Specific angiotensin II inhibition by saralasin vs Controls for baseline comparison…
Design
Cohort
Authors
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May improve hemodynamics in high-renin subsets; hypothesis-generating for angiotensin II blockade in normotensive heart failure.
Does angiotensin II inhibition by saralasin improve hemodynamics in normotensive patients with chronic congestive heart failure?
In normotensive patients with congestive heart failure, renin levels are elevated relative to filling pressures, and angiotensin II blockade can improve cardiac function by unloading the left ventricle.
Turini et al. (1978) studied this question.
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