Why the study?
Does angiotensin have different vascular effects compared to norepinephrine in the forelimb vessels of dogs, cats, and monkeys?
Population
Dogs, cats, and monkeys (constant-flow and natural-flow forelimb preparations)
Comparison
Angiotensin vs Norepinephrine
Design
Preclinical
Authors
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Animal data show differential angiotensin effects with tachyphylaxis; leaves open translation to human vascular responses.
Does angiotensin have different vascular effects compared to norepinephrine in the forelimb vessels of dogs, cats, and monkeys?
Angiotensin and norepinephrine exert species-specific differential effects on arterial and venous pressures in mammalian forelimb models, with rapid tachyphylaxis observed in small veins during angiotensin infusion.
Emerson et al. (1965) studied this question.
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