Comparison of Effects of Angiotensin and Norepinephrine on Pulmonary Circulation, Systemic Arteries and Veins, and Systemic Vascular Capacity in the Dog
Key result
Angiotensin II had no direct effect on pulmonary blood vessels or systemic vascular capacity in dogs, whereas norepinephrine acted as a pulmonary vasoconstrictor and potent venoconstrictor.
Authors
Discussion
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Implication
Canine data warrant no change in human vasopressor selection; leaves open direct pulmonary effects of angiotensin II.
Key Points
- This research aims to compare the effects of angiotensin II and norepinephrine on various aspects of vascular response in dogs.
- Dog experiments were conducted to assess the effects of angiotensin II and norepinephrine on pulmonary blood vessels and systemic vascular capacity.
- The study focused on the impact of these agents on systemic arteries and veins.
- Angiotensin II showed no direct effect on pulmonary blood vessels, unlike norepinephrine which caused pulmonary vasoconstriction.
- Angiotensin II did not affect veins or systemic vascular capacity, whereas norepinephrine significantly reduced systemic vascular capacity due to its strong venoconstrictor properties.
PICO
I
Intervention / Comparator
Angiotensin II vs Norepinephrine
O
Primary Outcome
Effects on pulmonary circulation, systemic arteries and veins, and systemic vascular capacity
Cite This Study
Rose et al. (1962) studied this question. Angiotensin II vs. Norepinephrine was evaluated on Effects on pulmonary circulation, systemic arteries and veins, and systemic vascular capacity. Angiotensin II had no direct effect on pulmonary blood vessels or systemic vascular capacity in dogs, whereas norepinephrine acted as a pulmonary vasoconstrictor and potent venoconstrictor.