What question did this study set out to answer?

To evaluate how local denervation and various vasoactive agents alter vascular pressures and transcapillary fluid movement in the canine forelimb.

October 1, 1961American Journal of Physiology-Legacy Content

Effects of denervation and vasoactive agents on vascular pressures and weight of dog forelimb

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Population

Dog forelimb model

Design

Preclinical

Authors

FHFrancis J. HaddyUniversity of Vermont JMJoyce I. MolnarNorthwestern University RCRichard W. CampbellNorthwestern University

Discussion

Member takes

Implication

Should not change clinical fluid management; leaves open the role of resistance ratios in human capillary water transfer.

Key Points

To evaluate how local denervation and various vasoactive agents alter vascular pressures and transcapillary fluid movement in the canine forelimb.
Infused vasoactive agents into the brachial artery of locally denervated, dependent dog forelimbs at rates avoiding large vessel pressure changes.
Continuously tracked limb weight along with small and large arterial and venous pressures.
Denervation, methacholine, serotonin, and histamine each elevated small venous pressure and increased the rate of limb weight gain.
Angiotensin and vasopressin reduced small venous pressure and slowed limb weight gain, whereas levarterenol produced mixed directional responses.
Capillary hydrostatic pressure and resulting tissue water storage depend directly on the balance between arterial and venous resistances.

Structured PICO

Population

Dog forelimb model

Intervention

Local denervation and infusion of vasoactive agents (angiotensin, vasopressin, methacholine, serotonin, histamine, levarterenol) into the brachial artery

Outcome

Forelimb weight and small and large arterial and venous pressuressurrogate

Local denervation and vasoactive agents alter water transfer across the capillary membrane by changing capillary hydrostatic pressure, highlighting the importance of arterial to venous resistance ratios.

Cite This Study

Haddy et al. (1961) studied this question.

synapsesocial.com/papers/6a70328426a7f98052dcb3d9 https://doi.org/10.1152/ajplegacy.1961.201.4.631

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Effects of denervation and vasoactive agents on vascular pressures and weight of dog forelimb

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of denervation and vasoactive agents on vascular pressures and weight of dog forelimb

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider