What does this research mean for the field?

Hypoxia uniquely potentiates the inotropic effects of two heptapeptide analogues of angiotensin II (1-des-5-Val and 1-des-5-Ile-angiotensin II) in cat myocardium, whereas it depresses the maximum response to ouabain and norepinephrine. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1972Circulation ResearchOpen Access

Inotropic Agents in Hypoxic Cat Myocardium

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Population

Papillary muscle preparations from normal cats and cats that had undergone previous total extrinsic cardiac…

Comparison

Inotropic agents under hypoxic conditions vs Same inotropic agents under control conditions

Design

Preclinical

Authors

KKKenneth M. KentBoston University TGTheodore L. GoodfriendGeneral / Preventive / Lipids ZMZena McCallumRoyal Children's Hospital

Discussion

Member takes

Implication

Hypoxia's selective effects on inotropes in animal tissue warrant in vivo validation; leaves open clinical translation to hypoxic states.

Structured PICO

Population

Papillary muscle preparations from normal cats and cats that had undergone previous total extrinsic cardiac denervation (catecholamine-depleted)

Intervention

Inotropic agents (ouabain, norepinephrine, angiotensin II, 1-des-5-Val-angiotensin II, 1-des-5-Ile-angiotensin II) under hypoxic conditions (5% O2 - 5% CO2 - 90% N2)

Comparator

Same inotropic agents under control conditions (95% O2 - 5% CO2)

Outcome

Inotropic response (tension and dose-response curves)surrogate

Hypoxia uniquely potentiates the inotropic effects of angiotensin II analogues in cat papillary muscles, in contrast to the depressed response seen with ouabain and norepinephrine.

Cite This Study

Kent et al. (1972) studied this question.

synapsesocial.com/papers/6a1be077b33628da419cf57f https://doi.org/10.1161/01.res.30.2.196

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February 1, 1972Circulation ResearchOpen Access

Inotropic Agents in Hypoxic Cat Myocardium

View Full Paper

Ask AI

Bookmark

Population

Papillary muscle preparations from normal cats and cats that had undergone previous total extrinsic cardiac…

Comparison

Inotropic agents under hypoxic conditions vs Same inotropic agents under control conditions

Design

Preclinical

Authors

KKKenneth M. KentBoston University TGTheodore L. GoodfriendGeneral / Preventive / Lipids ZMZena McCallumRoyal Children's Hospital

Discussion

Member takes

Implication

Hypoxia's selective effects on inotropes in animal tissue warrant in vivo validation; leaves open clinical translation to hypoxic states.

Structured PICO

Population

Papillary muscle preparations from normal cats and cats that had undergone previous total extrinsic cardiac denervation (catecholamine-depleted)

Intervention

Inotropic agents (ouabain, norepinephrine, angiotensin II, 1-des-5-Val-angiotensin II, 1-des-5-Ile-angiotensin II) under hypoxic conditions (5% O2 - 5% CO2 - 90% N2)

Comparator

Same inotropic agents under control conditions (95% O2 - 5% CO2)

Outcome

Inotropic response (tension and dose-response curves)surrogate

Hypoxia uniquely potentiates the inotropic effects of angiotensin II analogues in cat papillary muscles, in contrast to the depressed response seen with ouabain and norepinephrine.

Cite This Study

Kent et al. (1972) studied this question.

synapsesocial.com/papers/6a1be077b33628da419cf57f https://doi.org/10.1161/01.res.30.2.196

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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