What does this research mean for the field?

Bradykinin and angiotensin exert direct cardiac stimulating effects that are normally masked by baroreceptor reflexes in intact rats, and the positive inotropic action of angiotensin is at least partially mediated by catecholamines. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1965Circulation ResearchOpen Access

Cardiac Action of Vasoactive Polypeptides in the Rat

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Rats (intact, ganglionically blocked, and reserpinized)

Intervention

Intravenous and intra-arterial injection of bradykinin (0.01 to 0.02 µg IA; 12.5 and 25 µg/kg/min IV) and angiotensin

Comparator

Unblocked rats or pre-blockade state

Outcome

Hemodynamic responses including arterial pressure, cardiac output, heart rate, stroke volume, and total peripheral resistancesurrogate

Bradykinin and angiotensin exert direct cardiac stimulating effects in rats, which are modulated by autonomic reflexes in the intact animal.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

These rat findings warrant caution extrapolating to humans; leaves open mechanistic insights for translational research.

Cite This Study

Groß et al. (1965) studied this question.

synapsesocial.com/papers/6a1be077b33628da419cf584 https://doi.org/10.1161/01.res.16.2.150

View Full Paper

Ask AI

Bookmark

Cardiac Action of Vasoactive Polypeptides in the Rat

Structured PICO

Discussion

Implication

Cite This Study

Cardiac Action of Vasoactive Polypeptides in the Rat

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider