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November 3, 2004HypertensionOpen Access

Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension

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Why the study?

Does metabolic syndrome and/or essential hypertension increase resting muscle sympathetic nerve activity in closely matched subjects?

Population

69 closely matched subjects, comprising hypertensive metabolic syndrome, normotensive metabolic syndrome…

Comparison

Presence of metabolic syndrome and/or essential… vs Normotensive controls without metabolic syndrome

Design

Cross-sectional

Authors

RHRobert J. HuggettRussells Hall HospitalJBJoanna BurnsUniversity of LeedsAMAlan MackintoshUniversity of Leeds

Discussion

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Implication

Sympathetic hyperactivity was associated with metabolic syndrome plus hypertension; extends prior links but remains hypothesis-generating for risk reduction.

Structured PICO

Does metabolic syndrome and/or essential hypertension increase resting muscle sympathetic nerve activity in closely matched subjects?

P
Population
69 closely matched subjects, comprising hypertensive metabolic syndrome (MS+EHT, n=18), normotensive metabolic syndrome (MS-EHT, n=17), hypertensives without metabolic syndrome (EHT, n=16), and normotensive controls without metabolic syndrome (NC, n=18)
I
Intervention
Presence of metabolic syndrome and/or essential hypertension
C
Comparator
Normotensive controls without metabolic syndrome
O
Outcome
Resting muscle sympathetic nerve activity (MSNA) assessed from multiunit discharges and from single units with defined vasoconstrictor properties (s-MSNA)surrogate

Metabolic syndrome is associated with sympathetic nerve hyperactivity, which is further augmented by the presence of hypertension, potentially contributing to increased cardiovascular risk.

Cite This Study

Huggett et al. (2004) studied this question.

synapsesocial.com/papers/6a1be135ea84844e355f1c0dhttps://doi.org/10.1161/01.hyp.0000147893.08533.d8

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple Metabolic Syndrome Is Associated With Lower Heart Rate Variability: The Atherosclerosis Risk in Communities Study1998 · 222 citations
  2. 2The variability of muscle nerve sympathetic activity in resting recumbent man1977 · 443 citations
  3. 3Impact of Type 2 Diabetes Mellitus on Sympathetic Neural Mechanisms in Hypertension2003 · 308 citations
  4. 4Single-Unit Sympathetic Discharge1999 · 175 citations
  5. 5Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.1994 · 287 citations