Key result
Single-unit sympathetic discharge was significantly greater in stage 1 essential hypertension compared to stages 2/3 (63 vs 51 impulses/100 beats, P<0.05) and normal controls.
Why the study?
Does single-unit sympathetic discharge measurement (s-MSNA) better characterize sympathetic output in hypertensive disease compared to multiunit bursts (MSNA)?
Population
74 subjects with a wide range of arterial blood pressure
Comparison
Measurement of single-unit vasoconstrictor… vs Measurement of multiunit bursts (MSNA)
Design
Cross-sectional
Authors
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Sympathetic hyperactivity may peak in early hypertension; leaves open its causal role and therapeutic targeting.
Observational (n=74)
Does single-unit sympathetic discharge measurement (s-MSNA) better characterize sympathetic output in hypertensive disease compared to multiunit bursts (MSNA)?
p-value: p=<0.05
Quantification of single vasoconstrictor units provides evidence of increased central sympathetic output in established essential hypertension, and reveals augmented sympathetic output in mild/early stages compared to more severe hypertension.
Greenwood et al. (1999) conducted an observational in Hypertension (n=74). Hypertension (high normal and stages 1-3) vs. Normal blood pressure was evaluated on Single-unit sympathetic nerve activity (s-MSNA) (p=<0.05). Single-unit sympathetic discharge was significantly greater in stage 1 essential hypertension compared to stages 2/3 (63 vs 51 impulses/100 beats, P<0.05) and normal controls.
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