Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma
Why the study?
Does the eNOS exon 7 polymorphism increase the risk of ischemic stroke, TIA, or carotid atheroma in white patients?
Population
361 consecutive white patients presenting with ischemic stroke or TIA and 236 normal white controls
Comparison
Presence of endothelial nitric oxide synthase… vs Absence of the eNOS exon 7 polymorphism
Design
Case-control
Authors
Discussion
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Member takes
Implication
No support for genotyping in white patients; leaves open ancestry-specific or CAD-restricted effects.
Structured PICO
Does the eNOS exon 7 polymorphism increase the risk of ischemic stroke, TIA, or carotid atheroma in white patients?
P
Population
361 consecutive white patients presenting with ischemic stroke or TIA and 236 normal white controls
I
Intervention
Presence of endothelial nitric oxide synthase (eNOS) exon 7 polymorphism (894G-->T)
C
Comparator
Absence of the eNOS exon 7 polymorphism
O
Outcome
Ischemic stroke or TIAhard clinical
The eNOS exon 7 polymorphism (894G-->T) is not associated with ischemic cerebrovascular disease or the degree of carotid stenosis in white patients.
Cite This Study
Markus et al. (1998) studied this question.