Population
Small arteries (about 1 mm O.D.)
Comparison
Vasoconstriction induced by local application of… vs Control vessels
Design
Preclinical
Authors
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Fixation during vasoconstriction mimics hypertrophy histologically; challenges WT:L ratio as sole evidence of remodeling in animal models.
Normal vessels fixed during vasoconstriction exhibit increased wall thickness to lumen ratio similar to vascular hypertrophy, highlighting the importance of functional state during fixation.
Citters et al. (1962) studied this question.
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