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December 21, 1967New England Journal of Medicine

Lactate Metabolism in Anxiety Neurosis

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Why the study?

Does standard exercise cause excessive lactate production and evoke anxiety symptoms in patients with anxiety neurosis compared to normal matched controls?

Population

Patients with anxiety neurosis

Comparison

Standard exercise vs Normal matched controls

Design

Review

Authors

FPFerris N. PittsUniversity of Southern CaliforniaJMJames N. McClureWashington University in St. Louis

Discussion

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Implication

May accompany anxiety symptoms on exercise; hypothesis-generating for metabolic mechanisms in anxiety neurosis.

Structured PICO

Does standard exercise cause excessive lactate production and evoke anxiety symptoms in patients with anxiety neurosis compared to normal matched controls?

P
Population
Patients with anxiety neurosis
I
Intervention
Standard exercise
C
Comparator
Normal matched controls
O
Outcome
Blood lactic acid productionsurrogate

Patients with anxiety neurosis exhibit abnormal lactate metabolism and reduced work capacity during exercise, with lactate rises approximating those seen in arteriosclerotic heart disease.

Cite This Study

Pitts et al. (1967) studied this question.

synapsesocial.com/papers/6a1be44726cb5670aa9d11cehttps://doi.org/10.1056/nejm196712212772502
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NEUROCIRCULATORY ASTHENIA (ANXIETY NEUROSIS, EFFORT SYNDROME, NEURASTHENIA)1950 · 195 citations
  2. 2Life Situations, Emotions, and Neurocirculatory Asthenia (Anxiety Neurosis, Neurasthenia, Effort Syndrome)1951 · 160 citations
  3. 3A Comparison of the Exercise Response in Anxiety States and Normal Controls1946 · 58 citations
  4. 4PSYCHIATRIC SYNDROMES, ANXIETY SYMPTOMS AND RESPONSES TO STRESS IN MEDICAL STUDENTS1961 · 45 citations