Why the study?
Hyponatraemia frequently complicates aneurysmal subarachnoid haemorrhage and worsens outcomes, but whether fludrocortisone improves clinical outcomes remains unknown.
Does fludrocortisone improve functional outcomes at 6 months in adult patients with acute aneurysmal subarachnoid haemorrhage?
Population
Planned 524 adult patients with acute aSAH in Australia, New Zealand, and the United Kingdom
Comparison
14 days of fludrocortisone vs matching placebo
Design
Phase 3 randomised, blinded, placebo-controlled, multicentre trial
Follow-up
6 months
Authors
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This is a study protocol for a phase 3 trial evaluating whether 14 days of fludrocortisone improves 6-month functional outcomes in patients with acute aneurysmal subarachnoid hemorrhage.
Does fludrocortisone improve functional outcomes at 6 months in adult patients with acute aneurysmal subarachnoid haemorrhage?
This is a study protocol for a phase 3 trial evaluating whether 14 days of fludrocortisone improves 6-month functional outcomes in patients with acute aneurysmal subarachnoid hemorrhage.
Cohen et al. (2025) studied this question.
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