Why the study?
Do corticosteroids improve sodium and fluid balances, symptomatic vasospasm, and neurological outcomes in patients with aneurysmal subarachnoid hemorrhage?
Population
Patients with aneurysmal subarachnoid hemorrhage (SAH) from 7 observational, controlled clinical studies.
Comparison
Corticosteroids vs Control group
Design
Meta-analysis
Authors
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Corticosteroids should not be used to improve neurological outcomes in aneurysmal SAH; confirms no benefit on hard endpoints despite surrogate gains.
Do corticosteroids improve sodium and fluid balances, symptomatic vasospasm, and neurological outcomes in patients with aneurysmal subarachnoid hemorrhage?
Corticosteroids with mineralocorticoid activity help maintain sodium and volume homeostasis and may reduce symptomatic vasospasm in SAH patients, though they do not improve neurological outcomes.
Mistry et al. (2016) studied this question.
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