What question did this study set out to answer?

To determine whether prostaglandins physiologically antagonize the antidiuretic action of vasopressin in the mammalian kidney in vivo.

August 1, 1975Journal of Clinical InvestigationOpen Access

Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney.

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Authors

RARobert J. AndersonMayo Clinic in Arizona TBTomás BerlUniversity of Vermont KMKM McDonaldUniversity of Colorado Boulder

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Implication

In vivo animal study reveals that inhibiting prostaglandin synthesis enhances vasopressin-induced water retention in canines, indicating a physiological antagonism in the kidney.

Key Points

To determine whether prostaglandins physiologically antagonize the antidiuretic action of vasopressin in the mammalian kidney in vivo.
Conducted experiments in steroid-replaced, hypophysectomized dogs undergoing active water diuresis.
Administered two consecutive intravenous doses of vasopressin (100 mU), with the second dose preceded by either vehicle carrier, indomethacin (2 mg/kg), or meclofenamate (2 mg/kg).
Monitored urinary osmolality before and after each vasopressin challenge to detect changes in renal water reabsorption.
Carrier control administration showed no enhanced antidiuresis, with urinary osmolality rising from 92 ± 5 to 252 ± 18 mosmol/kg H2O (P < 0.0001) after dose one and from 109 ± 8 to 209 ± 10 mosmol/kg H2O (P < 0.001) after dose two.
Pretreatment with indomethacin significantly magnified the response to the second vasopressin dose, increasing urinary osmolality from 106 ± 14 to 702 ± 69 mosmol/kg H2O versus 93 ± 9 to 244 ± 33 mosmol/kg H2O for dose one (P < 0.001).
Pretreatment with meclofenamate similarly amplified the antidiuretic effect of the second vasopressin dose, elevating urinary osmolality from 101 ± 8 to 734 ± 86 mosmol/kg H2O versus 83 ± 7 to 216 ± 16 mosmol/kg H2O for dose one (P < 0.001).

Cite This Study

Anderson et al. (1975) studied this question.

synapsesocial.com/papers/6a1bea765b8f4ede65a93d6c https://doi.org/10.1172/jci108108

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Implication

In vivo animal study reveals that inhibiting prostaglandin synthesis enhances vasopressin-induced water retention in canines, indicating a physiological antagonism in the kidney.

Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney.

Discussion

Member takes

Implication

Key Points

Cite This Study

Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney.

Discussion

Member takes

Implication

Key Points

Cite This Study

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