August 27, 2003Journal of Hypertension
Angiotensin II type 1 receptor blockade prevents diastolic heart failure through modulation of Ca2+ regulatory proteins and extracellular matrix
Why the study?
Does candesartan cilexetil prevent diastolic heart failure and modulate Ca2+ regulatory proteins and extracellular matrix in a hypertensive rat model?
Population
Dahl salt-sensitive rats fed a diet containing 8% sodium chloride from 7 weeks of age (n=13)
Comparison
Subdepressor dose of an AT1R antagonist from 8… vs No treatment
Design
Preclinical
Follow-up
Up to around 20 weeks of age
Authors
Discussion
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Implication
Does not support clinical use in diastolic HF; extends preclinical evidence for BP-independent AT1R effects in rats.
Structured PICO
Does candesartan cilexetil prevent diastolic heart failure and modulate Ca2+ regulatory proteins and extracellular matrix in a hypertensive rat model?
P
Population
Dahl salt-sensitive rats fed a diet containing 8% sodium chloride from 7 weeks of age (n=13)
I
Intervention
Subdepressor dose of an AT1R antagonist (candesartan cilexetil) from 8 weeks of age
C
Comparator
No treatment
O
Outcome
Development of diastolic heart failure, left ventricular relaxation abnormality, and myocardial stiffeningsurrogate
AT1R blockade prevents diastolic heart failure in a hypertensive rat model via modulation of Ca2+-handling proteins and collagen phenotype, independent of blood pressure reduction.
Cite This Study
Sakata et al. (2003) studied this question.