What does this research mean for the field?

Alkali-metal salts like sodium and potassium exert a complex, biphasic effect on calcium uptake and binding in cardiac microsomes, but do not exhibit the specific Na+-Ca2+ competition proposed to control myocardial contractility. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

November 1, 1967Circulation ResearchOpen Access

Sodium and Potassium Sensitivity of Calcium Uptake and Calcium Binding by Dog Cardiac Microsomes

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Population

Dog cardiac microsomes purified on sucrose density gradients

Comparison

Varying concentrations of KCl and NaCl vs Different concentrations or absence of KCl and…

Design

Preclinical

Authors

AKArnold M. KatzHeart Failure / Cardiomyopathy DRDoris I. RepkeMount Sinai Hospital

Discussion

Member takes

Implication

Challenges Na+-Ca2+ competition model of contractility; hypothesis-generating in animal microsomes, needs intact-system validation.

Structured PICO

Population

Dog cardiac microsomes purified on sucrose density gradients

Intervention

Varying concentrations of KCl and NaCl

Comparator

Different concentrations or absence of KCl and NaCl

Outcome

Calcium uptake and calcium bindingsurrogate

The study demonstrates complex, concentration-dependent effects of sodium and potassium on calcium uptake and binding in dog cardiac microsomes, but does not find evidence for a specific Na+-Ca2+ competition site controlling myocardial contractility.

Cite This Study

Katz et al. (1967) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47d0 https://doi.org/10.1161/01.res.21.5.767

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November 1, 1967Circulation ResearchOpen Access

Sodium and Potassium Sensitivity of Calcium Uptake and Calcium Binding by Dog Cardiac Microsomes

View Full Paper

Ask AI

Bookmark

Population

Dog cardiac microsomes purified on sucrose density gradients

Comparison

Varying concentrations of KCl and NaCl vs Different concentrations or absence of KCl and…

Design

Preclinical

Authors

AKArnold M. KatzHeart Failure / Cardiomyopathy DRDoris I. RepkeMount Sinai Hospital

Discussion

Member takes

Implication

Challenges Na+-Ca2+ competition model of contractility; hypothesis-generating in animal microsomes, needs intact-system validation.

Structured PICO

Population

Dog cardiac microsomes purified on sucrose density gradients

Intervention

Varying concentrations of KCl and NaCl

Comparator

Different concentrations or absence of KCl and NaCl

Outcome

Calcium uptake and calcium bindingsurrogate

Cite This Study

Katz et al. (1967) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47d0 https://doi.org/10.1161/01.res.21.5.767

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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