November 1, 1984Circulation ResearchOpen Access

Sodium-sensitive calcium binding to sarcolemma-enriched preparations from canine ventricle.

View Full Paper

Ask AI

Bookmark

Population

Sarcolemma-enriched preparations from canine ventricle

Design

Preclinical

Authors

MFMary B. FrankisMedical University of South Carolina GLGeorge E. LindenmayerMedical University of South Carolina

Discussion

Member takes

Implication

Does not inform clinical calcium management; leaves open physiological relevance of these sites in intact cardiac systems.

Structured PICO

Population

Sarcolemma-enriched preparations from canine ventricle

Intervention

Exposure to monovalent cations (Na+, Li+, Cs+, K+, Rb+, choline) and divalent cations (Sr++, Ba++, Mg++, Mn++)

Outcome

Calcium binding characteristics (Kd and Bmax) and inhibition by sodiumsurrogate

The study identifies sodium-sensitive calcium-binding sites in canine ventricular sarcolemma with affinities capable of modulating intracellular free calcium.

Cite This Study

Frankis et al. (1984) studied this question.

synapsesocial.com/papers/6a8c65bbce55b7ff59bd5d9f https://doi.org/10.1161/01.res.55.5.676

View Full Paper

Ask AI

Bookmark

Sodium-sensitive calcium binding to sarcolemma-enriched preparations from canine ventricle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sodium-sensitive calcium binding to sarcolemma-enriched preparations from canine ventricle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider