What does this research mean for the field?

Intracoronary administration of nifedipine immediately prior to transluminal angioplasty induces regional cardioplegia and suppresses lactate production, thereby protecting the myocardium from ischemia during transient coronary occlusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 2, 1983European Heart Journal

Regional cardioplegia and cardioprotection during transluminal angioplasty, which role for nifedipine?

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Why the study?

Does intracoronary nifedipine prevent ischemia-induced lactate production and hemodynamic impairment during transluminal angioplasty in patients undergoing PTCA?

Population

25 patients undergoing transluminal angioplasty, including 11 patients assessed for hemodynamic response and…

Comparison

Direct intracoronary injection of nifedipine… vs Transluminal occlusion without nifedipine.

Design

Cohort

Follow-up

up to 90 seconds (during procedure)

Authors

PSP. W. SerruysThomas Jefferson University Hospital MBMarcel van den BrandBrigham and Women's Hospital RBRonald W. BrowerJohns Hopkins University

Discussion

Member takes

Implication

Intracoronary nifedipine may attenuate ischemia during PTCA; hypothesis-generating for calcium antagonists and requires randomized confirmation.

Structured PICO

Does intracoronary nifedipine prevent ischemia-induced lactate production and hemodynamic impairment during transluminal angioplasty in patients undergoing PTCA?

Population

25 patients undergoing transluminal angioplasty (PTCA), including 11 patients assessed for hemodynamic response and 14 patients assessed for lactate production during LAD PTCA.

Intervention

Direct intracoronary injection of nifedipine (0.2 mg) immediately prior to transluminal angioplasty (PTCA).

Comparator

Transluminal occlusion without nifedipine.

Outcome

Hemodynamic response (coronary sinus and great cardiac vein flow, left ventricular isovolumic contraction) and lactate production during transluminal occlusion.surrogate

Intracoronary nifedipine administered immediately prior to PTCA balloon occlusion suppresses lactate production and may protect the myocardium from transient ischemia.

Cite This Study

Serruys et al. (1983) studied this question.

synapsesocial.com/papers/6a1beff21567d2fc4d5f49dc https://doi.org/10.1093/eurheartj/4.suppl_c.115

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Implication

Intracoronary nifedipine may attenuate ischemia during PTCA; hypothesis-generating for calcium antagonists and requires randomized confirmation.

Regional cardioplegia and cardioprotection during transluminal angioplasty, which role for nifedipine?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional cardioplegia and cardioprotection during transluminal angioplasty, which role for nifedipine?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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