Why the study?
Does intravenous streptokinase increase thromboxane biosynthesis and platelet activation in patients with acute myocardial infarction?
Population
6 patients with acute myocardial infarction receiving intravenous streptokinase, compared to patients not…
Comparison
Intravenous streptokinase vs No thrombolytic therapy
Design
Cohort
Authors
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Streptokinase was associated with increased thromboxane biosynthesis in AMI; leaves open whether this attenuates efficacy and merits prospective trials.
Does intravenous streptokinase increase thromboxane biosynthesis and platelet activation in patients with acute myocardial infarction?
Intravenous streptokinase induces marked platelet activation and thromboxane A2 biosynthesis in patients with acute myocardial infarction, which may limit its therapeutic efficacy.
Fitzgerald et al. (1988) studied this question.
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