Why the study?
Does streptokinase combined with aspirin increase platelet activation compared to aspirin alone or no treatment in patients with acute myocardial infarction?
Population
30 patients with acute myocardial infarction in a coronary care unit
Comparison
Streptokinase 1.5 million units intravenously… vs 500 mg aspirin alone or neither thrombolysis nor…
Design
Cohort
Follow-up
2 days
Authors
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Thrombolysis may heighten platelet activation in AMI; leaves open whether intensified antiplatelet regimens improve outcomes in trials.
Does streptokinase combined with aspirin increase platelet activation compared to aspirin alone or no treatment in patients with acute myocardial infarction?
Thrombolysis with streptokinase significantly increases thromboxane production, indicating enhanced platelet activation that may necessitate more potent antiplatelet therapy.
Rasmanis et al. (1992) studied this question.
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