Why the study?
Does the AGT M235T polymorphism predict the rate of deterioration of creatinine clearance and maximal proteinuria in Caucasian patients with IgA nephropathy?
Does the AGT M235T polymorphism predict the rate of deterioration of creatinine clearance and maximal proteinuria in Caucasian patients with IgA nephropathy?
Polymorphisms at the AGT and ACE gene loci are important markers for predicting progression to chronic renal failure in Caucasian patients with IgA nephropathy.
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AGT M235T variants were associated with faster Ccr decline in IgA nephropathy; hypothesis-generating and should not yet change practice.
Pei et al. (1997) studied this question.
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