Why the study?
Do genetic polymorphisms of the renin-angiotensin system influence the clinical course and progression of IgA nephropathy?
Do genetic polymorphisms of the renin-angiotensin system influence the clinical course and progression of IgA nephropathy?
The AGT-M235T polymorphism, especially combined with ACE-I/D polymorphism, is an important marker of progression in IgA nephropathy.
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May identify high-risk IgA nephropathy patients; leaves open whether genotyping informs management.
Bantis et al. (2004) studied this question.
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