Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1975Journal of Applied Physiology

Dynamic stiffness profiles in the left ventricle

View Full Paper
Ask AI
Bookmark
Share

Population

open-chest, pentobarbital-anesthetized dogs

Design

Preclinical

Authors

AKA. KennishEYEdward L. YellinJerusalem College of TechnologyRFRobert W.M. FraterUniversity of the Free State

Discussion

Loading...

Member takes

Implication

Indicates rate-dependent LV diastolic stiffness in animals; extends exponential models but leaves open human translation.

Key Points

  • This research aims to characterize the dynamic stiffness profiles of the left ventricle during diastolic phases.
  • Calculated diastolic pressure-volume curves on a beat-to-beat basis in anesthetized dogs.
  • Used direct transmitral flow measurement to assess stiffness via dP/dV.
  • Monitored changes in stiffness across diastolic periods under varying conditions.
  • Identified exponential relation in end-diastolic P-V curves during volume loading.
  • Observed nonlinear dynamic dP/dV vs. pressure plots during diastolic phases.
  • In early diastole, the heart exhibited negative dP/dV, followed by a second stiffness rise with atrial augmentation.

Structured PICO

P
Population
open-chest, pentobarbital-anesthetized dogs
I
Intervention
Measurement of diastolic pressure-volume (P-V) curves using direct transmitral flow measurement
O
Outcome
Dynamic stiffness profiles (dP/dV vs pressure and time)surrogate

This preclinical study demonstrates that instantaneous left ventricular diastolic stiffness is nonlinear and rate-dependent, highlighting the complex viscoelastic properties of the myocardium.

Cite This Study

Kennish et al. (1975) studied this question.

synapsesocial.com/papers/6a1bf4856f692abb725efda3https://doi.org/10.1152/jappl.1975.39.4.665
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic determinants of letf ventricular diastolic pressure-volume relations in man.1975 · 144 citations
  2. 2Passive properties of canine left ventricle: diastolic stiffness and restoring forces.1988 · 228 citations
  3. 3A quantitative analysis of reservoir function of the human pulmonary "venous" system for the left ventricle.1986 · 9 citations
  4. 4The diastatic pressure-volume relationship is not the same as the end-diastolic pressure-volume relationship2008 · 33 citations
  5. 5Diastolic ventricular-vascular stiffness and relaxation relation: elucidation of coupling via pressure phase plane-derived indexes2006 · 23 citations