What does this research mean for the field?

Over the very long term (>10 years), patients with nonischemic cardiomyopathy have significantly higher survival following cardiac resynchronization therapy with defibrillator (CRT-D) compared to patients with ischemic cardiomyopathy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 25, 2025JACC AdvancesOpen Access

Very Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Ischemic and Nonischemic Cardiomyopathy

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Why the study?

While short- and medium-term outcomes after CRT have been extensively reported, data on very long-term outcomes (10+ years) remain limited.

Does nonischemic cardiomyopathy compared to ischemic cardiomyopathy improve very long-term survival in patients undergoing CRT-D?

Structured PICO

Does nonischemic cardiomyopathy compared to ischemic cardiomyopathy improve very long-term survival in patients undergoing CRT-D?

Population

610 matched patients with heart failure with reduced ejection fraction (EF ≤35%) and wide QRS (≥120 ms) who underwent cardiac resynchronization therapy with defibrillator therapy (CRT-D) at the Mayo Clinic.

Intervention

Cardiac resynchronization therapy with defibrillator (CRT-D) in patients with nonischemic cardiomyopathy (NICM)

Comparator

Cardiac resynchronization therapy with defibrillator (CRT-D) in patients with ischemic cardiomyopathy

Outcome

All-cause mortalityhard clinical

Over a very long-term follow-up of more than 10 years, patients with nonischemic cardiomyopathy have significantly higher survival post-CRT-D compared to those with ischemic cardiomyopathy.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Etiology should not yet guide CRT-D decisions; extends observational survival data to >10 years in NICM versus ICM.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/6a1bf49bea84844e355f39b0 https://doi.org/10.1016/j.jacadv.2025.101713

Topics

Cardiomyopathy Heart failure HFrEF treatment

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Very Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Ischemic and Nonischemic Cardiomyopathy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Very Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Ischemic and Nonischemic Cardiomyopathy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider