What does this research mean for the field?

Cardiac postganglionic sympathetic nerve stimulation does not attenuate the dynamic heart rate response to vagal stimulation via an alpha-adrenergic mechanism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 15, 2004AJP Heart and Circulatory Physiology

Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via α-adrenergic mechanism

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Why the study?

Does cardiac postganglionic sympathetic nerve stimulation affect the dynamic HR response to vagal stimulation via the alpha-adrenergic mechanism in rabbits?

Population

Seven anesthetized rabbits that had undergone sinoaortic denervation and vagotomy

Comparison

Beta-adrenergic blockade with propranolol and… vs Baseline and beta-adrenergic blockade alone

Design

Preclinical

Authors

TMTadayoshi MiyamotoOsaka Sangyo University TKToru KawadaUniversity of Chichester YYYusuke YanagiyaNational Cerebral and Cardiovascular Center

Discussion

Member takes

Implication

Alpha-adrenergic mediation of sympathetic-vagal heart rate interactions unsupported in rabbits; leaves open presynaptic mechanisms for human validation.

Structured PICO

Does cardiac postganglionic sympathetic nerve stimulation affect the dynamic HR response to vagal stimulation via the alpha-adrenergic mechanism in rabbits?

Population

Seven anesthetized rabbits that had undergone sinoaortic denervation and vagotomy

Intervention

Beta-adrenergic blockade with propranolol (1 mg/kg i.v.) and combined beta-adrenergic blockade and tonic cardiac sympathetic nerve stimulation at 5 Hz

Comparator

Baseline (vagal stimulation alone) and beta-adrenergic blockade alone

Outcome

Transfer function from vagal stimulation to heart rate (dynamic gain, corner frequency, pure delay)surrogate

Cardiac postganglionic sympathetic nerve stimulation does not affect the dynamic heart rate response to vagal stimulation via the alpha-adrenergic mechanism in a rabbit model.

Cite This Study

Miyamoto et al. (2004) studied this question.

synapsesocial.com/papers/6a1bf5eabc71fb1015a91dc7 https://doi.org/10.1152/ajpheart.00752.2003

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Implication

Alpha-adrenergic mediation of sympathetic-vagal heart rate interactions unsupported in rabbits; leaves open presynaptic mechanisms for human validation.

Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via α-adrenergic mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via α-adrenergic mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider