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April 5, 2016Scientific ReportsOpen Access

The summary HR per 1% increase in HbA1c level was 1.03 (95% CI 1.01-1.04) for all-cause mortality and 1.05 (95% CI 1.02-1.07) for CVD mortality, with a non-linear association rising steeply above 5.7%.

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Why the study?

Does higher HbA1c level increase the risk of all-cause and cause-specific mortality in subjects without known diabetes?

Population

Subjects without known diabetes from 12 prospective cohort studies

Comparison

Higher HbA1c levels (evaluated per 1% increase) vs Lower HbA1c levels

Design

Meta-analysis

Authors

GZGuo‐Chao ZhongMYMing-Xin YeJCJia-Hao Cheng

Discussion

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Member takes

Overview

May support HbA1c monitoring for mortality risk in non-diabetics; leaves open need for interventional trials.

Structured PICO

Does higher HbA1c level increase the risk of all-cause and cause-specific mortality in subjects without known diabetes?

P
Population
Subjects without known diabetes from 12 prospective cohort studies
I
Intervention
Higher HbA1c levels (evaluated per 1% increase)
C
Comparator
Lower HbA1c levels
O
Outcome
All-cause mortalityhard clinical

Higher HbA1c levels (>5.7%) are associated with increased all-cause and CVD mortality in subjects without known diabetes, primarily driven by those with undiagnosed diabetes or prediabetes.

Limitations

  • Limited studies for cancer mortality

Cite This Study

Zhong et al. (2016) studied this question.

synapsesocial.com/papers/6a1bf5f127b545b111a94389https://doi.org/10.1038/srep24071
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