What does this research mean for the field?

Patients with nonalcoholic fatty liver disease (NAFLD), even in the absence of morbid obesity, hypertension, and diabetes, exhibit altered left ventricular geometry and early signs of diastolic dysfunction that can be independently identified using early diastolic velocity on tissue Doppler imaging. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to determine the impact of metabolic syndrome on left ventricular geometry and function in patients with nonalcoholic fatty liver disease.

October 24, 2006Journal of Clinical Gastroenterology

Cardiac Abnormalities as a New Manifestation of Nonalcoholic Fatty Liver Disease: Echocardiographic and Tissue Doppler Imaging Assessment

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Why the study?

Does nonalcoholic fatty liver disease (NAFLD) alter left ventricular geometry and function in patients under 55 years of age without diabetes, hypertension, or morbid obesity?

Population

38 patients with nonalcoholic fatty liver disease, less than 55 years of age and with a normal exercise…

Comparison

Nonalcoholic fatty liver disease (NAFLD) vs Age and sex-matched control group

Design

Case-control

Authors

SGSorel GolandHeart Failure / Cardiomyopathy SSSara ShimoniHebrew University of Jerusalem TZTaiba ZornitzkiKaplan Medical Center

Discussion

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Implication

May indicate early diastolic dysfunction on TDI in young NAFLD patients without comorbidities; hypothesis-generating for causality and screening.

Key Points

This study aims to determine the impact of metabolic syndrome on left ventricular geometry and function in patients with nonalcoholic fatty liver disease.
Compared 38 patients with nonalcoholic fatty liver disease to a matched control group.
Conducted complete echocardiographic assessments including tissue Doppler imaging.
Excluded patients with diabetes, hypertension, and morbid obesity.
Patients with NAFLD showed higher body mass index (31.4 vs. 26.4 kg/m, P=0.01) and glucose levels (100.6 vs. 83.0 mg/dL, P=0.01).
Significant changes in left ventricular wall thickness and mass were noted (intraventricular septum: 11.03 vs. 8.9 mm, P=0.001).
Early diastolic velocity (E') on tissue Doppler imaging was a key independent marker associated with NAFLD.

Structured PICO

Does nonalcoholic fatty liver disease (NAFLD) alter left ventricular geometry and function in patients under 55 years of age without diabetes, hypertension, or morbid obesity?

Population

38 patients with nonalcoholic fatty liver disease (NAFLD), less than 55 years of age and with a normal exercise test. Excluded: patients with diabetes mellitus, hypertension, and body mass index >40.

Intervention

Nonalcoholic fatty liver disease (NAFLD)

Comparator

Age and sex-matched control group

Outcome

Left ventricular (LV) geometry and function assessed by echocardiography and tissue Doppler imaging (TDI)surrogate

NAFLD is independently associated with early features of left ventricular diastolic dysfunction and altered geometry, detectable by tissue Doppler imaging, even in the absence of morbid obesity, hypertension, and diabetes.

Cite This Study

Goland et al. (2006) studied this question.

synapsesocial.com/papers/6a1bf6451567d2fc4d5f5513 https://doi.org/10.1097/01.mcg.0000225668.53673.e6

Topics

Echocardiography

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Implication

May indicate early diastolic dysfunction on TDI in young NAFLD patients without comorbidities; hypothesis-generating for causality and screening.

Cardiac Abnormalities as a New Manifestation of Nonalcoholic Fatty Liver Disease: Echocardiographic and Tissue Doppler Imaging Assessment

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cardiac Abnormalities as a New Manifestation of Nonalcoholic Fatty Liver Disease: Echocardiographic and Tissue Doppler Imaging Assessment

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider