What does this research mean for the field?

Increasing extracellular calcium concentration decreases conduction velocity and increases internal longitudinal resistance in cardiac Purkinje fibers, an effect likely mediated by calcium influx through the Na+/Ca++ exchange mechanism rather than slow inward calcium channels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1982Circulation ResearchOpen Access

Effects of extracellular calcium ions, verapamil, and lanthanum on active and passive properties of canine cardiac purkinje fibers.

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Population

Isolated false tendons (canine cardiac Purkinje fibers)

Comparison

Alteration of extracellular calcium ion… vs Baseline conditions ([Ca++]o at 2 mM)

Design

Preclinical

Authors

MPMilton L. PresslerUniversity of Bern VEVictor ElharrarRichard L. Roudebush VA Medical Center JBJ C BaileyUniversity of Indianapolis

Discussion

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Implication

May implicate Na/Ca exchange in calcium effects on Purkinje resistance; hypothesis-generating for conduction mechanisms.

Structured PICO

Population

Isolated false tendons (canine cardiac Purkinje fibers)

Intervention

Alteration of extracellular calcium ion concentration ([Ca++]o) from 2 to 8 mM, with or without verapamil (3 X 10(-6) and 1 X 10(-5) M) or lanthanum (La+++ 0.2 mM)

Comparator

Baseline conditions ([Ca++]o at 2 mM)

Outcome

Active and passive electrophysiological properties (cellular excitability, conduction velocity, internal longitudinal resistance, capacitance)surrogate

Extracellular calcium-induced changes in internal longitudinal resistance in canine Purkinje fibers may occur via calcium influx through the Na+/Ca++ exchange mechanism.

Cite This Study

Pressler et al. (1982) studied this question.

synapsesocial.com/papers/6a1bf8811567d2fc4d5f5937 https://doi.org/10.1161/01.res.51.5.637

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Effects of extracellular calcium ions, verapamil, and lanthanum on active and passive properties of canine cardiac purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of extracellular calcium ions, verapamil, and lanthanum on active and passive properties of canine cardiac purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider