Three‐micro‐electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured?
Population
Calf cardiac Purkinje fibres
Comparison
Three-micro-electrode voltage clamp method vs Comparison between total applied current and…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Validates voltage clamp accuracy in animal Purkinje fibres; extends foundational tools for cardiac electrophysiology research while leaving clinical translation open.
Structured PICO
P
Population
Calf cardiac Purkinje fibres
I
Intervention
Three-micro-electrode voltage clamp method
C
Comparator
Comparison between total applied current (IT) and longitudinal voltage difference signal (delta V)
O
Outcome
Adequacy of measurements of slow inward current (agreement between delta V and IT)surrogate
The three-micro-electrode voltage clamp method provides a reliable and accurate measurement of slow inward current in cardiac Purkinje fibres.
Cite This Study
Kass et al. (1979) studied this question.