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January 1, 2020BioMed Research InternationalOpen Access

Network Pharmacology‐Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.‐Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy

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Why the study?

To explore the effects of the Hedysarum multijugum Maxim.-Radix Salviae compound (Huangqi-Danshen Compound) on oxidative capacity and cardiomyocyte apoptosis in rats with diabetic cardiomyopathy using a network pharmacology-based strategy.

Does Hedysarum multijugum Maxim.-Radix Salviae compound (HDC) improve oxidative capacity and cardiomyocyte apoptosis in rats with diabetic cardiomyopathy?

Population

Diabetic cardiomyopathy model rats

Comparison

Hedysarum multijugum Maxim.-Radix Salviae compound intervention

Design

Network pharmacology analysis and preclinical animal experiment

Authors

SZShiying ZhangZYZhiying YuanHWHuaying Wu

Discussion

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Member takes

Overview

Should not change practice; hypothesis-generating in rats and leaves open human translation for diabetic cardiomyopathy.

Structured PICO

Does Hedysarum multijugum Maxim.-Radix Salviae compound (HDC) improve oxidative capacity and cardiomyocyte apoptosis in rats with diabetic cardiomyopathy?

P
Population
Rats with diabetic cardiomyopathy (DCM model rats)
I
Intervention
Hedysarum multijugum Maxim.-Radix Salviae compound (Huangqi-Danshen Compound (HDC))
O
Outcome
Oxidative capacity (FPG, HbA1c, MDA, SOD, GSH-Px) and cardiomyocyte apoptosissurrogate

HDC improves diabetic cardiomyopathy in a rat model by reducing oxidative stress and modulating cardiomyocyte apoptosis.

Cite This Study

Zhang et al. (2020) studied this question.

synapsesocial.com/papers/6a1bfc75bc71fb1015a924d3https://doi.org/10.1155/2020/8260703
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Also Consider

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