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Reinforces preload dependence in stable myocardium; confirms experimental consensus while leaving clinical translation open.
Sequential experimental studies are reviewed which, when properly integrated, confirm the concept that the responses of the ventricles, however measured, are determined by the initial length of fibers, provided that the functional state of the myocardium is not altered. Some of the established factors are discussed which may obscure the evidence that this basic law is of importance under normal and pathologic conditions.
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Carl J. Wiggers (1951) studied this question.
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