Key result
Conflicting results exist regarding the interaction between the Gly460Trp α-adducin gene variant and blood-pressure response to thiazide diuretics, necessitating further research.
Further research is needed to clarify the conflicting evidence regarding the interaction between the Gly460Trp α-adducin gene variant and blood pressure response to thiazide diuretics.
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Clinicians should not genotype-guide thiazide use; leaves open the variant's role pending definitive trials.
Treatment with a thiazide diuretic is associated with large interindividual differences in blood-pressure reduction. Both environmental and genetic factors might play a role. Several individual polymorphisms have already been studied for association with blood-pressure response in patients treated with diuretics. α-adducin is one of the more extensively studied polymorphisms. Unfortunately, conflicting results have been found in different populations. More research is needed to unravel the possible interactions between diuretics and the α-adducin polymorphism.
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Wijer et al. (2008) conducted an editorial in Hypertension. Thiazide diuretics was evaluated. Conflicting results exist regarding the interaction between the Gly460Trp α-adducin gene variant and blood-pressure response to thiazide diuretics, necessitating further research.
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