What question did this study set out to answer?

This review aims to explore the molecular pathways involved in angiotensin II-induced cardiac effects, particularly in fibroblasts.

Angiotensin II, adhesion, and cardiac fibrosis

View Full Paper

Ask AI

Bookmark

This review aims to explore the molecular pathways involved in angiotensin II-induced cardiac effects, particularly in fibroblasts.
Review of existing literature on angiotensin II and its effects on cardiac myocytes and fibroblasts.
Analysis of molecular pathways such as MAP kinase associated with cardiac remodeling.
Discussion of the roles of various factors like norepinephrine and endothelin in cardiac hypertrophy.
Angiotensin II promotes cardiac myocyte hypertrophy through a MAP kinase dependent pathway.
It induces cardiac fibroblast proliferation and the production of adhesion molecules and extracellular matrix proteins.
Angiotensin II enhances adhesion of fibroblasts to matrixes, which may contribute to cardiac fibrosis.

Design

Review

No takes yet. Share an insight, caveat, or question.

Highlights Ang II's role in remodeling; leaves open whether targeted inhibition alters clinical outcomes.

Janet Schnee (2000) studied this question.

View Full Paper

Ask AI

Bookmark