Key result
Angiotensin II and hypertension induce cardiac fibrosis and remodeling by triggering inflammatory responses, leukocyte infiltration, and myofibroblast formation.
Design
Review
Authors
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Highlights inflammatory pathways as potential targets in hypertensive remodeling; leaves open clinical translation pending interventional studies.
Understanding the inflammatory pathways driven by Angiotensin II in hypertensive heart disease may identify new targets for preventing cardiac remodeling.
Lixin Jia (2011) conducted a review in Hypertension-induced cardiac remodeling. Angiotensin II was evaluated. Angiotensin II and hypertension induce cardiac fibrosis and remodeling by triggering inflammatory responses, leukocyte infiltration, and myofibroblast formation.
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