What does this research mean for the field?

Excess extracellular calcium causes frog ventricles to exhibit multiple firing and sustained contraction in response to a single electrical stimulus by localizing the response through partial blocking, which leads to a net gain in ventricular calcium content. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1970The Japanese Journal of PhysiologyOpen Access

Multiple Firing of Frog's Ventricle in Response to a Single Stimulus in Ringer's Solution With Excess Calcium

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Population

Frog's ventricle

Design

Preclinical

Authors

YFYasuichiro FukudaChiba University

Discussion

Member takes

Implication

Caution against clinical extrapolation from frog data; leaves open calcium effects on ventricular excitability for mammalian studies.

Structured PICO

Population

Frog's ventricle

Intervention

Single direct electrical stimulus in Ringer's solution with excess calcium (~8 times normal concentration)

Outcome

Multiple firing accompanied by a long continued contractionsurrogate

Excess calcium induces multiple firing and sustained contraction in frog ventricles following a single electrical stimulus due to localized response from partial blocking.

Cite This Study

Yasuichiro Fukuda (1970) studied this question.

synapsesocial.com/papers/6a1c0ddf1567d2fc4d5f836d https://doi.org/10.2170/jjphysiol.20.42

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Multiple Firing of Frog's Ventricle in Response to a Single Stimulus in Ringer's Solution With Excess Calcium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Multiple Firing of Frog's Ventricle in Response to a Single Stimulus in Ringer's Solution With Excess Calcium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider