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October 1, 1977Circulation ResearchOpen Access

Mechanism of activation of contraction in frog ventricular muscle.

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Population

Frog ventricular muscle strips

Design

Preclinical

Authors

TAThomas W. AndersonUnited States Geological SurveyCHCharlesT.W. HirschLaboratoire Adaptations Travail-IndividuFKFrederic KavalerState University of New York

Discussion

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Implication

Transsarcolemmal Ca influx suffices in frog ventricle; leaves open SR dependence in mammalian cardiomyocytes.

Structured PICO

P
Population
Frog ventricular muscle strips
I
Intervention
Changes in extracellular ionic composition (calcium, sodium, manganese) and displacement of transmembrane potential
O
Outcome
Force of contraction and transmembrane potentialsurrogate

This preclinical study provides evidence that transsarcolemmal calcium influx is the exclusive source of calcium for activation of contraction in frog ventricular muscle.

Cite This Study

Anderson et al. (1977) studied this question.

synapsesocial.com/papers/6a849bf4c3be978f8d8d9b92https://doi.org/10.1161/01.res.41.4.472
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions1966 · 425 citations
  2. 2Postextrasystolic Potentiation of Contraction in Cardiac Muscle1956 · 166 citations
  3. 3Regenerative Calcium Release within Muscle Cells1970 · 395 citations
  4. 4Calcium‐sodium antagonism on the frog's heart: a voltage‐clamp study.1976 · 63 citations
  5. 5Effects of calcium on the contraction of the hypodynamic frog heart1970 · 56 citations