This article provides a comprehensive review of the structural, electrical, and contractile mechanisms of activation in skeletal and cardiac striated muscle.
Synthesizes mechanisms of striated muscle activation; extends foundational research while leaving open clinical translation.
The sections in this article are: Structure of Striated Muscle Contractile Mechanism Internal Membrane System Comparative Anatomy of Internal Membrane System Resting Electrical Properties of Skeletal Muscle Ionic Permeability Resting Electrical Properties of Internal Membrane System Detubulated Muscle Excitation in Skeletal Muscle Ionic Basis of Action Potential Inward Spread of Activation T‐system Conductance Changes in Frog Twitch Fibers Excitation‐Contraction Coupling in Skeletal Muscle Calcium Activation of Contractile Mechanism Calcium Transport and Storage in SR Mechanism of Calcium Release Role of SR ‐T Junction in E‐C Coupling Membrane Potential and Contractile Activation Time Course of Calcium Release: Calcium Transient Contractile Activation Without Membrane Depolarization Electrical Events Associated with Activation Role of Extracellular Calcium in Contractile Activation Calcium‐Sodium Exchange Pharmacological Alterations of E‐C Coupling Cellular Organization of Cardiac Muscle Resting Electrical Properties of Cardiac Muscle Ionic Permeability Membrane Capacity and Resistance Action Potential in Mammalian Cardiac Muscle Ionic Basis of Action Potential Voltage‐Clamp Studies of Mammalian Cardiac Muscle Purkinje Fiber Preparation Outward Currents in Purkinje Cells Inward Currents in Purkinje Cells Ventricular Myocardial Preparations Ionic Currents in Myocardial Preparations Ionic Basis of Plateau Potential ‐ Summary Action Potential in Frog Myocardial Cells Voltage‐Clamp Studies of Frog Cardiac Muscle Frog Myocardial Preparations Ionic Currents in Frog Myocardium E‐C Coupling in Cardiac Muscle Calcium Influx and Alterations in SR Calcium Stores Calcium Influx and Contractile Activation
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L. L. Costantin (1977) studied this question.
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