Key result
Sacubitril/valsartan significantly improved KCCQ physical and social activities compared with enalapril, with the largest improvement in household chores (adjusted change score difference 2.35; P<.001).
Why the study?
Does sacubitril/valsartan improve physical and social activity limitations in patients with heart failure with reduced ejection fraction compared to enalapril?
RCT (n=8,399)
double-blind
randomized
Yes
Does sacubitril/valsartan improve physical and social activity limitations in patients with heart failure with reduced ejection fraction compared to enalapril?
Effect estimate: Adjusted change score difference 2.35 (95% CI 1.19-3.50)
p-value: p=<.001
In patients with HFrEF, sacubitril/valsartan significantly improves patient-reported physical and social activity limitations, such as household chores and sexual relationships, compared to enalapril.
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Supports sacubitril/valsartan over enalapril for activity limitations in HFrEF; extends trial benefits to patient-reported physical and social functioning.
Chandra et al. (2018) conducted an RCT in Heart failure with reduced ejection fraction (n=8,399). Sacubitril/valsartan vs. Enalapril, 10 mg twice daily was evaluated on Components of the physical and social limitation sections of the KCCQ at 8 months and longitudinally (Adjusted change score difference 2.35, 95% CI 1.19-3.50, p=<.001). Sacubitril/valsartan significantly improved KCCQ physical and social activities compared with enalapril, with the largest improvement in household chores (adjusted change score difference 2.35; P<.001).
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