In Taiwanese type 2 diabetic patients, independent risk factors for peripheral arterial disease were age, lower BMI, and systolic blood pressure in men, and age, uric acid, and insulin use in women.
Cross-Sectional (n=610)
No
What are the sex-specific risk factors for peripheral arterial disease in Taiwanese patients with type 2 diabetes?
Risk factors for peripheral arterial disease in type 2 diabetic patients differ significantly by sex, highlighting the need for sex-specific risk assessment.
Absolute Event Rate: 11.1% vs 8.6%
p-value: p=>0.1
BACKGROUND: There appear to be sex differences in the risk factors for peripheral arterial disease (PAD) in type 2 diabetic patients, but studies in Taiwanese patients have not been conducted. METHODS AND RESULTS: A total of 610 (268 men, 342 women) Taiwanese patients aged 63.3+/-10.8 years were evaluated. PAD was diagnosed by an ankle - brachial index <0.9. Risk factors included age, sex, body mass index (BMI), waist circumference (WC), smoking, menopause, diabetes duration, hypertension, insulin therapy, systolic and diastolic blood pressures, fasting glucose, total cholesterol (TC), triglyceride (TG), high- (HDL-C) and low-density lipoprotein-cholesterol (LDL-C), apolipoproteins A1 (ApoA1) and B (ApoB) and uric acid (UA). When compared with the men, the women were significantly older and had longer duration, smaller WC, higher levels of systolic blood pressure, TC, TG, HDL-C, LDL-C, ApoA1 and ApoB, lower levels of UA, fewer smokers and more insulin users. Stepwise logistic regression showed age, BMI (inverse association) and systolic blood pressure as independent risk factors for men respective odds ratios (OR): 1.080 (1.024-1.139), 0.832 (0.713-0.971) and 1.028 (1.005-1.051); and for women they were age, UA and insulin therapy [respective OR: 1.113 (1.056-1.173), 1.340 (1.101-1.630) and 4.173 (1.974-8.824). CONCLUSIONS: PAD risk factors differ significantly between the sexes.
Chin‐Hsiao Tseng (Mon,) conducted a cross-sectional in Type 2 diabetes mellitus (n=610). Risk factor profiling vs. Men vs Women was evaluated on Peripheral arterial disease (ABI <0.9) (p=>0.1). In Taiwanese type 2 diabetic patients, independent risk factors for peripheral arterial disease were age, lower BMI, and systolic blood pressure in men, and age, uric acid, and insulin use in women.