Key result
Three-dimensional PISA EROA accurately differentiated severe tricuspid regurgitation with an AUC of 0.958, demonstrating different optimal cut-offs for primary (0.49 cm2) and secondary (0.41 cm2) etiologies.
Why the study?
TR quantification using 3D PISA derived EROA is feasible in functional TR, but its diagnostic accuracy and utility required exploration in a larger population across different etiologies.
Does 3D PISA EROA accurately quantify tricuspid regurgitation severity and provide incremental diagnostic value over 2D echocardiography in patients with confirmed TR?
Observational (n=107)
No
Does 3D PISA EROA accurately quantify tricuspid regurgitation severity and provide incremental diagnostic value over 2D echocardiography in patients with confirmed TR?
3D PISA EROA is a feasible and accurate method for quantifying tricuspid regurgitation severity across different etiologies, providing incremental diagnostic value over clinical symptoms and 2D echocardiography.
Background The quantification of tricuspid regurgitation(TR) using three-dimensional(3D) proximal isovelocity surface area (PISA) derived effective regurgitant orifice area (EROA) is feasible in functional TR. The aim of our study was to explore the diagnostic accuracy and utility of 3D PISA EROA in a larger population of different etiologies. Methods One hundred and seven patients with confirmed TR underwent 2D and 3D transthoracic echocardiography (TTE). 3D PISA EROA was calculated and EROA derived from 3D regurgitant volume (Rvol) was used as the reference. Results 3D PISA EROA showed better correlation in primary TR than in functional TR(r = 0.897, P < 0.01). 3D PISA EROA differentiated severe TR with comparable accuracy in patients with primary and functional etiology (Z-value 16.506 vs 21.202), but with different cut-offs (0.49cm 2 vs. 0.41 cm 2 ). The chi-square value for incorporated clinical symptoms, positive echocardiographic results and 3D PISA EROA to grade severe TR was higher than only included clinical symptoms or incorporated clinical symptoms and positive echocardiographic results (chi-square value 137.233, P < 0.01). Conclusion TR quantification using 3D PISA EROA is feasible and accurate under different etiologies. It has incremental diagnostic value for evaluating severe TR.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2020) conducted an observational in Tricuspid regurgitation (n=107). 3D PISA EROA (Three-dimensional proximal isovelocity surface area effective regurgitant orifice area) vs. 3D Rvol EROA (volumetric method) was evaluated on Diagnostic accuracy to differentiate severe tricuspid regurgitation (AUC 0.958, p=<0.01). Three-dimensional PISA EROA accurately differentiated severe tricuspid regurgitation with an AUC of 0.958, demonstrating different optimal cut-offs for primary (0.49 cm2) and secondary (0.41 cm2) etiologies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: