Key result
Understanding the mechanisms of platelet interactions and cellular crosstalk in coronary artery disease supports the clinical importance of current and future antithrombotic therapies.
Understanding platelet interactions and cellular crosstalk provides a background for current anti-platelet therapies and future antithrombotic developments in coronary artery disease.
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Reinforces rationale for antithrombotic therapies in CAD; leaves open optimal targeting of platelet crosstalk for future trials.
Platelets play a significant role in coronary artery disease through interactions with each other and with other cell types. These interactions are mediated by certain receptors on the surface of platelets and other cells which can lead to intra-coronary thrombus formation and occlusion that may result in acute coronary syndromes. The important roles of the currently available anti-platelet therapies have been well established in many clinical outcome trials in cardiovascular patients. An understanding of these different interactions provides the clinician with a background that supports the clinical importance of currently available anti-platelet therapies. Moreover, knowledge of the mechanisms of cellular crosstalk will lead to important advances in the development of better antithrombotic therapies.
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Samara et al. (2003) conducted a review in Coronary artery disease. Anti-platelet therapies was evaluated. Understanding the mechanisms of platelet interactions and cellular crosstalk in coronary artery disease supports the clinical importance of current and future antithrombotic therapies.
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