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January 1, 1983Journal of Biological ChemistryOpen Access

In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases.

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Population

In vitro model using peptide analogs of angiotensin, src gene product of Rous sarcoma virus, and epidermal…

Design

Preclinical

Authors

TWTai W. WongBristol-Myers Squibb (United States)AGA R GoldbergMicrosoft (United States)

Discussion

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Implication

In vitro angiotensin phosphorylation data; leaves open any role in human cardiovascular kinase pathways.

Structured PICO

P
Population
In vitro model using peptide analogs of angiotensin, src gene product (pp60src) of Rous sarcoma virus, and epidermal growth factor-receptor kinase of A431 cells
I
Intervention
Phosphorylation by tyrosyl protein kinases and application of phosphatase inhibitors (p-nitrophenyl phosphate and sodium vanadate)
O
Outcome
Phosphorylation kinetics (Km and Vmax) and identification of phosphorylated residuessurrogate

Angiotensin analogs can be phosphorylated on tyrosine residues by viral and cellular tyrosyl protein kinases in vitro, and p-nitrophenyl phosphate and sodium vanadate effectively inhibit phosphotyrosine phosphatases in this system.

Cite This Study

Wong et al. (1983) studied this question.

synapsesocial.com/papers/6a1c189fbc71fb1015a93d3dhttps://doi.org/10.1016/s0021-9258(18)33153-3
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthetic peptide substrates for a tyrosine protein kinase.1982 · 183 citations
  2. 2Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase.1976 · 206 citations
  3. 3Protein kinase activity associated with the avian sarcoma virus src gene product.1978 · 1,133 citations
  4. 4Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line.1982 · 192 citations